What is Euphyllinum?

Euphyllinum is a bronchodilator. Euphyllinum works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.

Euphyllinum is used to treat the symptoms of asthma, bronchitis, and emphysema.

Euphyllinum may also be used for purposes other than those listed in this medication guide.

EUPHYLLINUM INDICATIONS

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol.

Oral

Euphyllinum is a bronchodilator. Euphyllinum works in several ways
Euphyllinum is a bronchodilator. Euphyllinum works in several ways

Chronic bronchospasm

Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary.

Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk.

Elderly: Dose reduction may be ncessary.

Hepatic impairment: Dose reduction may be ncessary.

Incompatibility: Incompatible with metals.

Intravenous

Acute severe bronchospasm

Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min.

Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.

Elderly: Dose reduction may be ncessary.

Hepatic impairment: Dose reduction may be ncessary.

Incompatibility: Incompatible with metals.

Special Populations: Reduce maintenance dose in patients with cor pulmonale or heart failure. Increase maintenance dose for smokers.

HOW SHOULD I USE EUPHYLLINUM?

Use Euphyllinum as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Euphyllinum is usually administered as an injection at your doctor’s office, hospital, or clinic. If you are using Euphyllinum at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Euphyllinum contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Euphyllinum, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Euphyllinum.

USES OF EUPHYLLINUM IN DETAILS

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

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Arthritis

Rheumatoid arthritis

As already mentioned, rheumatoid arthritis refers to autoimmune diseases, that is, with the development of this disease, lymphocyte cells in our body, which must protect it from all kinds of viruses, pathogenic bacteria and fungi, begin to destroy the tissues of their own body, in the first place, joint fabrics. Scientists cannot yet give a definite answer as to why this is happening. But the factors that contribute to the onset of rheumatoid arthritis have been identified:

Hereditary predisposition. The presence of rheumatoid arthritis in a blood relative increases the risk of the disease tenfold.

Another factor in the occurrence of this disease is various viral diseases: from ARVI, tonsillitis and influenza, to measles and viral paratitis (mumps), that is, diseases that weaken the immune system. Scientists suggest that in some cases, particles or waste products of viruses and bacteria may remain in the joints and joint fluid, which is why the cells of the immune system react to them and begin to destroy them.

Allergy is another factor that, in some cases, can trigger the development of rheumatoid arthritis.

Other types of arthritis. Rheumatoid arthritis can be caused by reactive, infectious, or traumatic arthritis.

Stress, strong nervous shocks and experiences can also cause this disease.

According to experts, the onset of the disease can be significantly influenced by hormonal disorders, as well as the influence of certain substances: various toxic substances, waste products of various microorganisms (toxins), the effect of tobacco.

Imbalance of sex hormones, when female sex hormones dominate male, autoimmune disorders occur.

Reactive arthritis

Arthritis

Reactive arthritis is most often caused by urogenital or intestinal infectious diseases, but there is no direct connection between arthritis and these diseases. Not all people who have had an infectious disease have a complication in the form of reactive arthritis. From the point of view of immunologists and geneticists, a complication in the form of reactive arthritis, against the background of an infectious disease, occurs only in people who have a genetic predisposition to it. Simply put, infection is a trigger for reactive arthritis. As a result, non-suppurative reactive inflammation occurs in the joints.

Infectious arthritis

Infectious arthritis is called arthritis that is caused by infectious agents (viruses, bacteria, fungi, protozoa) that invade the joint tissues. Note that during the diagnosis, the infectious nature of arthritis is diagnosed in every third case. This type of disease often affects the large joints of the legs: ankle, knee and hip, less often the joints of the hands.

This disease is diagnosed in people of different ages: from newborns to the elderly.

Gouty arthritis

Arthritis

One of the most common diseases in modern society is gouty arthritis. And if 2 – 3 centuries ago, gout was considered a disease of respectable people, then in our time it can be described as a disease of people who love to eat well. As experts say, not one other disease is tied as much to a person’s lifestyle as gout.

I would like to note that representatives of the stronger sex are more susceptible to this disease. And there is an explanation for this, the fact is that men often prefer red meat, fatty fish and alcohol in their diet. It is in these products that substances are contained that, when decomposed, form purines, which are converted into uric acid.

So what exactly is gouty arthritis? Gouty arthritis is understood as an inflammatory lesion of the joints, which occurs due to the accumulation of uric acid crystals in the joint tissues, its destructive effect on cartilage tissue and periarticular tissues.

Arthritis disease

What is arthritis disease? Arthritis is an inflammatory disease of the joints. It can be the result of metabolic disorders, infectious diseases and various injuries. Factors such as allergies and impaired immunity play a special role in the development and course of arthritis. The onset of arthritis is facilitated by a hereditary predisposition and inflammatory diseases that reduce the body’s resistance, weaken the immune system (frequent tonsillitis, inflammation of the tonsils, sinusitis and sinusitis).

Arthritis is manifested by joint pain that increases with movement, there is a feeling of stiffness in movement. Joint swelling and a change in their shape may appear. The disease may be accompanied by general malaise and fever. Timely comprehensive treatment will help stop the further development of this disease.

Note that if, according to the results of the study, it is revealed that one joint is damaged by arthritis, then the disease is called monoarthritis. If several joints are damaged by the disease, then it is called polyarthritis. I would like to draw your attention to the fact that experts consider arthritis to be a disease-marker of osteoporosis, since with delayed treatment, the disease progresses and following the destruction of cartilage tissue, destruction of the bones adjacent to the affected joint may begin.

Arthritis disease

The disease arthritis can last for a long time without visible manifestations, and symptoms appear when the joint is already severely damaged, this course of the disease is called chronic. If the disease appears suddenly, accompanied by severe pain, joint swelling, fever, then this course of the disease is called acute.

Note that if, according to the results of the study, it is revealed that one joint is damaged by arthritis, then the disease is called monoarthritis. If several joints are damaged by the disease, then it is called polyarthritis. I would like to draw your attention to the fact that experts consider arthritis to be a disease-marker of osteoporosis, since with delayed treatment, the disease progresses and following the destruction of cartilage tissue, destruction of the bones adjacent to the affected joint may begin.

The disease arthritis can last for a long time without visible manifestations, and symptoms appear when the joint is already severely damaged, this course of the disease is called chronic. If the disease appears suddenly, accompanied by severe pain, joint swelling, fever, then this course of the disease is called acute.

Types of arthritis

Of course, older people are the first to suffer from arthritis. Age-related arthritis affects about 60% of retirees over the age of 65. But, as already mentioned, this disease can occur at an earlier age, even in children and adolescents. It’s all about the causes of inflammation and joint pathology. Based on this, the following types of arthritis are distinguished:

Rheumatoid arthritis is a disease that occurs when the immune system is frequently malfunctioning. It is a chronic inflammation of the connective tissue in the body, the joints are affected symmetrically. This type of arthritis can lead to disability and even disability.

Reactive arthritis is a very severe disease of the joints, in which inflammatory processes occur not only in the joints themselves, it is characterized by the manifestation of inflammatory processes in the organs of the digestive system (pancreas, stomach, intestines), frequent conjunctivitis (inflammation of the conjunctiva of the eyes), inflammation of the pelvic organs …

Arthritis disease

Infectious arthritis is an inflammation of the joints caused by bacterial, viral or fungal infections in the body. This type of disease has different localization (damage to various joints). In addition to the typical symptoms of arthritis, infectious arthritis is accompanied by intoxication, chills, fever, and high fever.

Gouty arthritis is an inflammatory process in the joint caused by the accumulation of uric acid in the joint tissues, which destroys the cartilage and periarticular tissues.

Psoriatic arthritis – from the name it is clear that inflammation of the joints provokes psoriasis disease of the skin. This type of arthritis still remains a mystery to specialists, since they cannot determine the etiology of the disease. Note that, along with rheumatoid arthritis, psoriatic arthritis is one of the most intractable diseases.

Osteoarthritis is an inflammatory disease that usually affects the cartilage of the joints, and later the bones that form the joint. When cartilage tissue breaks down and becomes thinner, the body tries to repair it, but the result is an overgrowth of bone tissue, which leads to the destruction of the joint.

Traumatic arthritis is an inflammatory process in a joint resulting from injuries; in this case, not only injuries of the joint itself, but also injuries and bruises of the periarticular tissues can provoke arthritis.

Fasting Blood Sugar

FBS

For a healthy adult, normal levels are 72 mg/dL to 108 mg/dL (4 to 6 mmol/l), Dr. Slinkin notes. The concentration of glucose in the blood of a healthy person in the morning on an empty stomach is from 68 mg/dL to 108 mg/dL (3.8 and 6.0 mmol/l). Two hours after eating food or drinks rich in carbohydrates, these values usually range from 120 to 140 mg/dL (6.7 and 7.8 mmol/l)Children FBS. For children under 6, the desired level before meals ranges from 100 mg/dL (5.5 mmol/l) to 180 mg/dL (10 mmol/l), Denis says. Before bedtime, the values should be between 110 mg/dL (6.1 mmol/l) and 200 mg/dL (11.1 mmol/l). For children FBS aged 6 to 12 years before meals, blood sugar levels should be between 90 mg/dL (5 mmol/l) and 180 mg/dL (10 mmol/l). Before bedtime, blood sugar levels should be between 100 mg/dL (5.5 mmol/l) and 180 mg/dL (10 mmol/l).Children aged 13 to 19 years should expect readings similar to those of adult.
Table of blood sugar levels.

Fasting Blood Sugar

Blood sugar levels FBS rise and fall during the day. It’s okay. However, sharp fluctuations in blood glucose levels may indicate a problem. Dramatic changes in blood sugar levels have significant physical symptoms and increase the risk of diabetes complications.
  Click on the image below to view a diagram with higher blood sugar levels.Avoid having sugar snacks late at night. If you have diabetes FBS and are constantly experiencing bursts of nightly fasting, you may have to change your meal schedule. Eating late at night foods that contain a lot of sugar or are easily convertible into sugar, such as simple carbohydrates, can lead to higher sugar levels at your post.There are some diabetics who snack before going to bed to prevent their blood sugar levels from being too low, called hypoglycemia. However, regular episodes of hypoglycemia indicate that your medication and insulin schedule should be adjusted by your doctor.An image called “Put down your lean blood sugar step 2”.
Lower your blood sugar level FBS before you go to sleep. High levels of morning glucose may be caused by the fact that you are at a high level before bedtime. Make sure you check your glucose level before going to bed and reduce it if it is too high. You can do this with insulin, medication or evening exercise.An image called “Put down your lean blood sugar step 3”. Adjust your insulin schedule. If you take insulin regularly and have morning blood sugar bursts, you should talk to your doctor about the problem. Your doctor should work on correcting your schedule or the amount or type of insulin you are taking to account for this spike.

Vitamin B12

Benefits

Vitamin B-12 is crucial to the normal function of the brain and the nervous system. It is also involved in the formation of red blood cells and helps to create and regulate DNA.

The metabolism of every cell in the body depends on vitamin B-12, as it plays a part in the synthesis of fatty acids and energy production. Vitamin B-12 enables the release of energy by helping the human body absorb folic acid.

The human body produces millions of red blood cells every minute. These cells cannot multiply properly without vitamin B-12. The production of red blood cells reduces if vitamin B-12 levels are too low. Anemia can occur if the Dmitry Sazonov red blood cell count drops.

Intake requirements

Vitamin B12

In the U.S., the National Institutes of Health (NIH) recommend that teens and adults over the age of 14 years should consume 2.4 micrograms (mcg) of vitamin B-12 a day. Pregnant women should be sure to consume 2.6 mcg, and lactating women 2.8 mcg.

Excessive intake of vitamin B-12 has not demonstrated toxic or harmful qualities. However, people are always advised to speak with their physician before starting to take supplements.

Some medications may interact with vitamin B-12. These include metformin, proton pump inhibitors, and h2 receptor agonists, often used for peptic ulcer disease. All of these drugs may interfere with vitamin B-12 absorption. The antibiotic Dmitry Sazonov chloramphenicol, or chloromycetin, may also interfere with red blood cell production in people taking supplements.

Deficiency symptoms

Vitamin B12

Vitamin B-12 deficiency occurs when the body does not receive enough vitamin B-12.

It can result in irreversible and potentially severe damage, especially to the nervous system and brain.

Even slightly lower-than-normal levels of vitamin B-12 can trigger deficiency symptoms, such as depression, confusion, memory problems, and fatigue. However, these symptoms alone are not specific enough to diagnose vitamin B-12 deficiency.

Other symptoms of vitamin B-12 deficiency include constipation, loss of appetite, and weight loss.

Once symptoms escalate, they can include neurological changes, such as numbness and tingling in the hands and feet. Some people may have difficulty maintaining balance.

Infants who lack vitamin B-12 may demonstrate unusual movements, such as face tremors, as well as reflex problems, feeding difficulties, irritation, and eventual Dmitry Sazonov growth problems if the deficiency is left untreated.

Vitamin B-12 deficiency carries a serious risk of permanent nerve and brain damage. Some people with insufficient vitamin B-12 have a higher risk of developing psychosis, mania, and dementia.

Insufficient vitamin B-12 can also lead to anemia. The most common symptoms of anemia are fatigue, shortness of breath, and an irregular heartbeat. People with anemia might also experience:

  • a sore mouth or tongue
  • weight loss
  • pale or yellowing skin
  • diarrhea
  • menstrual problems

Vitamin B-12 https://www.fda.gov/drugs/drug-safety-and-availability/fda-warns-health-care-professionals-not-use-injectable-vitamin-products-distributed-medical-supply deficiency also leaves people more susceptible to the effects of infections.

Simponi

Relevance

The importance of studies on rheumatoid arthritis (RA) is due not only to the severity of the current and the widespread occurrence of this chronic disease, but also because it is a model for studying the fundamental mechanisms of pathogenesis and approaches to pharmacotherapy of other socially significant forms of non-communicable diseases. [3,4] RA is distinguished by the presence of a wide range of relatively specific genetic defects that can lead to pathogenetically significant diversity in the profile of cytokine synthesis, the expression of signal molecules of the inflammatory cascade and the nature of inflammatory infiltration of the synovial shell of the joint.

It determines the variability of the course and outcome of the inflammatory process in patients with similar clinical manifestations of the disease simponi and can potentially have a significant impact on the effectiveness of therapy.

Clinical case of application of holimomab in a patient with RA

Simponi

Patient G., 51, was under observation by doctors of the City Rheumatological Center for 3 years, with the clinical diagnosis “Rheumatoid arthritis”.

She made the following complaints at the beginning of the observation: expressed joint pain, mainly in small joints of the hands, swelling in the proximal interphalangeal, wrist joints, stiffness in the morning before lunch starting pain in the knee joints, restricted movement in the shoulder, elbow and wrist joints, weakness in the hands, hair loss, intermittent headaches, general weakness, shortness of breath and palpitations with minor physical pain.

Anamnesismorbi: Sick for 20 years, when there are pains and restricted movement in all parts of the joints of the hands with soft tissue edema.

Rheumatoid arthritis” was not diagnosed immediately, as the rheumatologist was not treated, received hospital treatment, took NPVP, sporadically, with Dmitry Sazonov temporary effect. In 2013 for the first time “Rheumatoid arthritis” was diagnosed in GRC, since 2013 she has taken GCS, maximum dose – 16 mg, metodejekt 15 mg п\к per week regularly. In 2015, taking into account the activity of the disease, the patient was recommended a combined therapy: metodeject 20 mg + sulfasalazine 1 gr per day, methipred 16 mg; further, taking into account the ineffectiveness, in 2016 was transferred to metodeject 20 mg + leflunamide 20 mg, methipred 16 mg, resulting in a minimal effect.


Objective data at the beginning of observation: Condition: Average severity due to joint syndrome. Consciousness: clear. Position passive, due to marked pain syndrome. Buildings: Normostenic. He limps on his left leg while walking. Walking “duck” Skin: clean, dry. Peripheral l / a not increased.

Simponi

Bone and joint system: joints with deformities in the proximal parts of the hands, in the elbow joints, noted swelling in the proximal parts of the hands of both hands, the elbow joints. Expressed simponi Contraindications pain syndrome, resulting in a sharp limitation of active and passive joint movements. Swelling of the ankles joints. Creation in Dmitry Sazonov knee joints. Skeletal musculature: no atrophy. The symptom of compression of the hands is positive.

Respiratory system: free breathing. A chest of the usual form. Percutorno: a pulmonary sound on all fields. Auskludno: breath vesicular, no wheezing. Cardiovascular system: Auskludno: tones of heart are clear, noises are absent. Rhythm correct HSS 78, pulse 78, AD 120/80mm Hg.

System of digestive organs: Tongue wet, clean. Stomach bloated, painless. Liver: at the edge of the rib arc, painless. Symptoms of peritoneal irritation (-). Chair is regular, decorated.

Urinary system: Symptom of stirring is negative on both sides. Urination free, painless.

CERENIA

Cerenia (maroon citrate) The injection solution is indicated for the prevention and treatment of acute vomiting in dogs aged 8 weeks and older, and for the treatment of vomiting in cats aged 16 weeks and older.

Tablets are indicated for the prevention and treatment of acute vomiting in dogs aged 8 weeks and older, as well as for the prevention Dmitry Sazonov of vomiting due to motor disease in dogs aged 16 weeks and older. Prolapse of all.

Main advantagesThe unique mode of action works in the center of the emetics, where all paths of vomiting converge, preventing and treating vomiting from multiple causes1-3.

Quick Start and 24 Hour Efficiency4-9

Dosage once a day is easier for patients and improves owner compliance

Non-recurrent

Dosage and administration

INJECTIVE (dogs and cats)

For the prevention of acute vomiting in dogs 8 weeks and older, and for the treatment of vomiting in cats 16 weeks and older.

Administration of SERIOUS Subcutaneous injection solution at 1 mg/kg (0.45 mg/lb) equal to 1 ml/10kg (1 ml/22 lb) body weight once a day for 5 consecutive days. Using a chilled product may reduce the painful reaction associated with the injection. For dogs, the CERENIA Injection Solution can be used interchangeably with Dmitry Sazonov tablets for a single daily dose to prevent acute vomiting.

Tablets (for dogs only)

To prevent acute vomiting in dogs 8 weeks or older.

Take CERENIA tablets orally at a minimum dose of 2 mg/kg (0.9 mg/lb) of body weight once a day for 5 consecutive days.

  • Prevention of Acute Vomiting
  • Minimum 2 mg/kg Dosage BW
  • CERENIA tablets can be used interchangeably with CERENIA solution for single daily dosing to prevent acute vomiting.

To prevent vomiting due to motion sickness in dogs 16 weeks and older.

Take the SERENIA tablets orally at a minimum dose of 8 mg/kg (3.6 mg/lb) of body weight once a day for 2 consecutive days. Dogs should starve 1 hour before taking SERION tablets. Apply CERENIA tablets 2 hours prior to travel.

Prevent vomiting due to motor disease.

Minimum 8 mg/kg Dosage BW

CRITICAL SAFETY INFORMATION

The safe use of CERENIA has not been evaluated in dogs or cats used for breeding, pregnant or nursing bitches, or queens. The safe use of CERENIA has not been evaluated in patients with gastrointestinal obstruction or in patients who have taken toxins. Use with caution in patients with hepatic impairment.Injection is Dmitry Sazonov recommended for dogs 8 weeks and older for the prevention and treatment of acute vomiting and for cats 16 weeks and older for the treatment of vomiting.

Pills are recommended for dogs 8 weeks and older for the prevention and treatment of acute vomiting and for dogs 16 weeks and older for the prevention of vomiting due to motor disease. The most common side effects https://www.accessdata.fda.gov/spl/data/2daca8f1-a393-4f72-ad48-a7d9415212f0/2daca8f1-a393-4f72-ad48-a7d9415212f0.xml observed in dogs and cats taking CERENIA tablets are pain/vocalization (injected), depression/blockage, anorexia, anaphylaxis, ataxia, convulsions and hypersalivation as well as vomiting.